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The desired effects include altered sensations, increased energy, empathy, as well as pleasure. When taken by mouth, effects begin in 30 to 45 minutes and last 3 to 6 hours

Results of several studies show the effects of increased empathy with others. When testing MDMA for medium and high doses, it showed increased hedonic and arousal continuum.

The effect of MDMA increasing sociability is consistent, while its effects on empathy have been more mixed.

Uses of MDMA

How do people use cocaine?

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People snort cocaine powder through the nose, or they rub it into their gums. Others dissolve the powder and inject it into the bloodstream. Some people inject a combination of cocaine and heroin, called a Speedball.

Another popular method of use is to smoke cocaine that has been processed to make a rock crystal (also called "freebase cocaine"). The crystal is heated to produce vapors that are inhaled into the lungs. This form of cocaine is called Crack, which refers to the crackling sound of the rock as it's heated. Some people also smoke Crack by sprinkling it on marijuana or tobacco, and smoke it like a cigarette.

People who use cocaine often take it in binges—taking the drug repeatedly within a short time, at increasingly higher doses—to maintain their high.

How does cocaine affect the brain?

Cocaine increases levels of the natural chemical messenger dopamine in brain circuits related to the control of movement and reward.

Normally, dopamine recycles back into the cell that released it, shutting off the signal between nerve cells. However, cocaine prevents dopamine from being recycled, causing large amounts to build up in the space between two nerve cells, stopping their normal communication. This flood of dopamine in the brain’s reward circuit strongly reinforces drug-taking behaviors. With continued drug use, the reward circuit may adapt, becoming less sensitive to the drug. As a result, people take stronger and more frequent doses in an attempt to feel the same high, and to obtain relief from withdrawal.Buy cocaine Powder

Short-Term Effects

Short-term health effects of cocaine include:

• extreme happiness and energy
• mental alertness
• hypersensitivity to sight, sound, and touch
• irritability
• paranoia—extreme and unreasonable distrust of others

Some people find that cocaine helps them perform simple physical and mental tasks more quickly, although others experience the opposite effect. Large amounts of cocaine can lead to bizarre, unpredictable, and violent behavior.Buy cocaine Powder

Cocaine's effects appear almost immediately and disappear within a few minutes to an hour. How long the effects last and how intense they are depend on the method of use. Injecting or smoking cocaine produces a quicker and stronger but shorter-lasting high than snorting. The high from snorting cocaine may last 15 to 30 minutes. The high from smoking may last 5 to 10 minutes.

What are the other health effects of cocaine use?

Other health effects of cocaine use include:

• constricted blood vessels
• dilated pupils
• nausea
• raised body temperature and blood pressure
• fast or irregular heartbeat
• tremors and muscle twitches
• restlessness

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What is ketamine?

The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

Ketamine is used by medical practitioners and veterinarians as an anaesthetic. It is sometimes used illegally by people to get Ketamine can produce psychedelic effects, causing a person to see, hear, smell, feel or taste things that aren’t really there or are different from how they are in reality.

Other names

Special K, K, ket, kitkat, super k, horse tranquilliser or horse trank.

The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

 They only contain ketamine hydrochloride and solvent; the method of obtaining the active principle in solid form consists of slow-drying in an oven at a medium temperature of 90-100º C.

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The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

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The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

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• The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

With this substance, in low doses, you get a peaceful, dreamy feeling similar to laughing gas. Users report the sensation of floating slightly out of their bodies. Numbness in the limbs is also common.

Higher doses produce a hallucinogenic effect that can make the user feel very far from their body.  Many users find the experience spiritually significant, while others go through it frightened.

When a person is in a “K hole,” it is challenging to move, they remain seated or lying down during the experience, it is the safest.

Mechanisms of action

After 10-20 minutes of consumption, depending on doses, its effects begin to appear, with different times for each of them.

The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

The total duration of the effects of consumption would be around two hours.

 Ketamine Side effects

It produces hallucinations, flashbacks, alteration of attention, and memory.

Also, bradycardia, hypertension, arrhythmias, mild respiratory depression, laryngospasm, stridor in children, and dystonic reactions.

, it can cause increased intracranial and intraocular pressure, seizures, cardiorespiratory failure, polyneuropathy, trismus, and muscular hypertonia after an overdose.

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Contraindications and Interactions

It is contraindicated in cases of:

• ketamine allergy,
• eclampsia (tonic-clonic seizures),
• arterial hypertension,
• heart failure
• patients prone to hallucinations.

It mainly interacts with:

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• barbiturates and benzodiazepines (need more recovery time),
• theophylline (antiasthmatic, bronchodilator): co-administration can cause seizures.

In laboratory tests, Ketamine alters some determinations: there is an increase in transaminases, cortisol, creatinine kinase, and luteinizing hormone.

The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied.

by the absence/imperception of pain (analgesia).

On the other hand, we can observe a decrease in testosterone.

    Ketamine contraindicated in the case of one of the following diseases:

• The first is the sensation of dissociation, appearing a state of unconsciousness and later very intense amnesia accompanied by the absence/imperception of pain (analgesia).

Can a person overdose on cocaine?

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Yes, a person can overdose on cocaine. An overdose occurs when a person uses enough of a drug to produce serious adverse effects, life-threatening symptoms, or death. An overdose can be intentional or unintentional.

Death from overdose can occur on the first use of cocaine or unexpectedly thereafter. Many people who use cocaine also drink alcohol at the same time, which is particularly risky and can lead to overdose. Others mix cocaine with heroin, another dangerous—and deadly—combination.

Some of the most frequent and severe health consequences of overdose are irregular heart rhythm, heart attacks, seizures, and strokes. Other symptoms of cocaine overdose include difficulty breathing, high blood pressure, high body temperature, hallucinations, and extreme agitation or anxiety.

How can a cocaine overdose be treated?

There is no specific medication that can reverse a cocaine overdose. Management involves supportive care and depends on the symptoms present. For instance, because cocaine overdose often leads to a heart attack, stroke, or seizure, first responders and emergency room doctors try to treat the overdose by treating these conditions, with the intent of:

• restoring blood flow to the heart (heart attack)
• restoring oxygen-rich blood supply to the affected part of the brain (stroke)
• stopping the seizure

How does cocaine use lead to addiction?

promethazine codeine As with other drugs, repeated use of cocaine can cause long-term changes in the brain’s reward circuit and other brain systems, which may lead to addiction. The reward circuit eventually adapts to the extra dopamine caused by the drug, becoming steadily less sensitive to it. As a result, people take stronger and more frequent doses to feel the same high they did initially and to obtain relief from withdrawal.

Withdrawal symptoms include:

• depression
• fatigue
• increased appetite
• unpleasant dreams and insomnia
• slowed thinking

How can people get treatment for cocaine addiction?

Behavioral therapy may be used to treat cocaine addiction. Examples include:

• cognitive-behavioral therapy
• contingency management or motivational incentives—providing rewards to patients who remain substance free
• therapeutic communities—drug-free residences in which people in recovery from substance use disorders help each other to understand and change their behaviors
• community based recovery groups, such as 12-step programs
• lead to addiction. The reward circuit eventually adapts to the extra dopamine caused by the drug, becoming steadily less sensitive to it. As a result, people take stronger and more frequent doses to feel the same high they did initially and to obtain relief from withdrawal.
• lead to addiction. The reward circuit eventually adapts to the extra dopamine caused by the drug, becoming steadily less sensitive to it. As a result, people take stronger and more frequent doses to feel the same high they did initially and to obtain relief from withdrawal.